An interesting opinion review article was recently published in Frontiers in Pediatrics, and discusses ME/CFS research about the immune system, microbiome, metabolome, and other fields, and then uses this information to generate a hypothesis on ME/CFS symptoms. The authors also put forward some interesting hypotheses on potential new treatment approaches.
ME/CFS has been strongly linked to infectious agents, including Epstein Barr Virus (EBV), Lyme disease, Herpes Virus 6 (HHV6), and many others. But researchers have been unable to pinpoint a definite infectious agent. The primary author of the review, Amy Proal, argues that since many well-studied inflammatory conditions are now being tied to dysbiosis, or disruption, of the human microbiome, initial infection with various agents could be causing similar clusters of inflammatory symptoms seen in ME/CFS.