‘Gut-on-a-chip’ System Shows Intestinal Epithelial Barrier Disruption Initiates Gut Inflammation

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Biomedical engineering assistant professor Hyun Jung Kim with the gut-on-a-chip. Source: Cockrell School of Engineering, The University of Texas at Austin

A new study in PNAS has linked the interaction between the intestinal epithelial barrier, the gut microbiome, and immune cells to intestinal inflammation. It is thought that the gut microbiota and immune cells contribute to gut inflammation, but until now, it has been difficult to identify exactly what triggers the onset of intestinal inflammation due to the complexity of the cross-talk between the multiple different cell types.

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