Insights into [ME/CFS] Phenotypes through Comprehensive Metabolomics

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A recent study in the journal Scientific Reports from Dr. W. Ian Lipkin, who is the Principal Investigator for the Columbia ME/CFS Center, has new metabolic and microbiome findings that could lead to the development of a diagnostic biomarker for ME/CFS. The article, titled “Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics,” details the analysis of plasma metabolomic, fecal bacterial metagenomic, and clinical data from 50 ME/CFS patients and 50 healthy controls. Metabolomics, which is the study of metabolites, or the end products of cellular processes, can give insight about the physiological state of the body, and how it is functioning.

The group analyzed 562 different molecules of the metabolome in subject blood samples using mass spectrometry, and then linked that data to fecal metagenomic data and clinical data. When all of the data was combined, the group was able to develop a predictive model for ME/CFS diagnosis with a 0.836 score, or an accuracy rate of 84 percent. In an article by Medical News Today about the study, first author Dr. Dorottya Nagy-Szakal is quoted, saying, “this is a strong predictive model that suggests we’re getting close to the point where we’ll have lab tests that will allow us to say with a high level of certainty who has this disorder.”

Solve ME/CFS Initiative Webinar Series: Derya Unutmaz, M.D.

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Source: solvecfs.org

On July 19th, Derya Unutmaz will participate in the Solve ME/CFS Initiative (SMCI) Webinar Series, a free series with the purpose of educating patients, researchers, and healthcare providers about ME/CFS. The webinars are held several times per year, and are live-streamed and later uploaded to Youtube for the community to watch. Derya’s webinar, titled “Crossroad of the Immune Response and the Microbiome: Impact on ME/CFS,” will provide an overview on how the microbiome can impact the immune system, and how dysbiosis of the microbiome could cause a perturbation of this interaction, contributing to the pathophysiology of ME/CFS. Participants can register for the webinar on SMCI’s website, and can then send in questions ahead of time that will be asked during the webinar.

To register for the webinar on SMCI’s website, click here. 

Advocate Spotlight: Charmian Proskauer

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We are pleased to present Charmian Proskauer, an ME/CFS advocate and former cell biologist and website manager, in the latest “People in ME/CFS Research” spotlight. Charmian is the President of the Massachusetts CFIDS Association, and has participated in many advocacy initiatives at both the state and federal levels as part of the organization. She is also the Chair of the US Action Working Group, and participates in some of the working groups for Chronic Fatigue Syndrome Advisory Committee (CFSAC). Charmian  and a group of patients and advocates from Mass CFIDS visited Derya and me at Jackson Labs several months ago, where they provided us with valuable insight. Keep reading to find out more about how Charmian began advocating for ME/CFS, and some of the latest initiatives she’s involved in. 

Continue reading “Advocate Spotlight: Charmian Proskauer”

Bateman Horne Center Article: BHC Strives for Excellence

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Bateman Horne Center (BHC), located in Salt Lake City, UT, just published a new article about their rigorous 3.5-year strategic plan to become a center for excellence for ME/CFS and Fibromyalgia (FM). BHC, a specialized medical center focused on treating patients with ME/CFS and FM, and our clinical core for the JAX ME/CFS CRC, is intent on improving the lives of patients and therefore is focusing on a three-phase plan to engage patients in research to further the field, educate healthcare providers to improve clinical care for patients, and focus on targeted clinical trials to address the heterogeneity of ME/CFS and FM. According to their mission statement, they “envision a world where patients with ME/CFS and Fibromyalgia (FM) are readily diagnosed, effectively treated, and widely met with empathy and understanding.”

To read about the strategic plan on Bateman Horne Center’s website, click here.